Methods for detection of HCV components (I)

• Anti HCV screening test: Elisa-3

96% sensitive, 90-95% specific ? F+ve

up to 25% in blood donors

? 7-8 weeks after infection

• Anti HCV confirmatory test: Riba-3, Innolia

Mostly useful in low prevalence settings

• HCV antigen

Qualitative: early detection

Quantitative: therapy monitoring

Alternative to PCR assays with lower sensitivity cut-off: 50.000 IU/ml

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